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Similar to the human GCLC, up-regulation of the human GCLM by β-NF involved binding of transcription factor Nrf2 (possibly in complexes with other Jun or Maf proteins as in GCLC) to a functional ARE/EpRE site located at −302 of the human GCLM [104,134]

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It is worth noting that some adverse reactions, such as nausea, vomiting, and allergy, may occur during NAC treatment