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Though RNA i -targeted prdx-3 knockdown worms had no difference in lifespan, they exhibited increased mitochondrial uncoupling, with lower ATP levels, motility, and reproduction, indicating that while prdx-3 silencing does not affect lifespan under these conditions, it is important for healthspan [183]
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theorized ferroptosis may be the primary form of cell death responsible for the development of h-ARS [67]
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