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Functional studies in neurons and cell lines under physiologic conditions, again utilizing voltage-gated calcium channel modulation by MOR, have also failed to detect constitutive MOR activity after chronic exposure to morphine in locus coeruleus (Connor et al., 1999) and periaqueductal gray neurons (Bagley et al., 2005b) or ShSY5Y cells (Kennedy and Henderson, 1992)

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G6PD is the first and rate limiting enzyme of the pentose phosphate pathway and catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP + to NADPH

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